Proteolix
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News

News Releases

   July 10, 2008 Proteolix Initiates Phase 1b Clinical Trial of Carfilzomib in a
Combination Regimen for Patients with Relapsed Multiple Myeloma
   May 15, 2008 Proteolix Appoints Thomas Kassberg Executive Vice President of Corporate Development
    May 1, 2008 Proteolix Initiates Phase 2 Clinical Trial of Carfilzomib in Patients with
Relapsed Solid Tumors
     April 2, 2008
Proteolix’s Carfilzomib Receives Orphan Drug Designation
for Treatment of Multiple Myeloma
    February 25, 2008
Proteolix Names Matthew Ferguson to Newly-Created Position of Chief Financial Officer
     December 6, 2007 Proteolix Announces Clinical Results with Carfilzomib
to be Reported at ASH 2007 Annual Meeting
     October 10, 2007 Proteolix Initiates Multicenter Open-label Study of the Safety and
Activity of Carfilzomib in Subjects with Relapsed Solid Tumors
     August 15, 2007 The Multiple Myeloma Research Consortium (MMRC) and Proteolix initiate Phase 2 clinical trial investigating Carfilzomib for the treatment of Multiple Myeloma
     May 24, 2007 Interim Clinical Results on Carfilzomib to be Presented at ASCO 2007
     April 26, 2007 Proteolix Hires Dr. Lori Kunkel as Chief Medical Officer
     January 16, 2007 Proteolix Elects Dr. Michael Kauffman Chairman of the Board -
Brings Extensive Drug Discovery and Clinical Development Experience
     May 31, 2006 Proteolix Announces Closing of $45 million Series B Financing.  Funding To Be
Used to Expand Clinical Trials.

Publications

    2007 Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res. 2007 Jul 1;67(13):6383-91. Demo SD, Kirk CJ, Aujay MA, Buchholz TJ, Dajee M, Ho MN, Jiang J, Laidig GJ, Lewis ER, Parlati F, Shenk KD, Smyth MS, Sun CM, Vallone MK, Woo TM, Molineaux CJ, Bennett MK
    2007 Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against pre-clinical models of multiple myeloma. Blood. 2007 Jun 25. Kuhn DJ, Chen Q, Voorhees PM, Strader JS, Shenk KD, Sun CM, Demo SD, Bennett MK, van Leeuwen FW, Chanan-Khan AA, Orlowski RZ.

Recent & Upcoming Presentations

December 2007

American Society of Hematology Annual Meeting [Atlanta, Dec. 8-11]

Safety and Anititumor Efficacy of the Proteasome Inhibitor Carfilzomib (PR-171) Dosed for Five Consecutive Days in Hematologic Malignancies: Phase 1 Results

Phase 1 Single Agent Antitumor Activity of Twice Weekly Consecutive Day Dosing of the Proteasome Inhibitor Carfilzomib (PR-171) in Hematologic Malignancies

Anti-tumor Activity of Immunoproteasome Selective Inhibitors

    November 2007 American College of Rheumatology Meeting [Boston, November 6–11]
Anti-Rheumatic effect of a selective inhibitor of the immunoproteasome
   October 2007 AACR/NCI/EORTC International Conference, Molecular Targets and Cancer Therapeutics
Pharmacodynamic, pharmacokinetic and anti-tumor properties of orally bioavailable inhibitors of the 20S proteasome
    June 2007 ASCO Annual Meeting
Phase I evaluation of carfilzomib (PR-171) in hemotological malignancies: Responses in multiple myeloma and Waldenstrom's macroglobulinemia at well-tolerated doses.
    April 2007 AACR Annual Meeting
Development of peptide epoxyketone-based proteasome inhibitors
   

 

 

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